Protein–Carbohydrate Interactions in Infectious Diseases
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Author(s): C. A. Bewley (Ed.)
Publisher: Royal Society of Chemistry
ISBN: 0854048022
Format: hardback
250pp
Price: £74.95
Review Date: 03 October 2006
Review: This book aims to educate and inform graduate students and other readers on the central role that protein–carbohydrate interactions play in mediating and initiating most infectious diseases, and the indispensable roles that chemistry and structural and cell biology play in studying these interactions. The eleven chapters include: An overview of the atomic basis for protein–carbohydrate interactions; The role of phenolic glycolipid and lipoarabinomannan in mycobacterial glycolipids and the host; The structure and role of Pseudomonas aeruginosa; Protein–carbohydrate interactions in enterobacterial infections; GMI glycomimetics and bacterial enterotoxins; retrocyclins; C-Type lectin receptors that regulate pathogen recognition through recognition of carbohydrates; Targeting microbial sialic acid metabolism for drug development; Synthetic carbohydrate-based antimalarial vaccines and glycobiology; Studies towards a rationally-designed conjugate vaccine for cholera; and Microarrays for high-throughput analysis of protein–carbohydrate interactions.