HLA in Health and Disease
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Author(s): R. Lechler and A. Warrens (Eds)
Publisher: Academic Press
ISBN: 0124403158
Format: hardback
472pp
Price: £94.95
Review Date: 31 May 2000
Review: This new edition has been updated and rewritten with several new authors. It begins by summarising current knowledge on the structure, function, genetics and evolution of the human leocyte antigen (HLA) system. It clarifies it complex nomenclature and discusses the mechanism underlying disease associated with HLA alleles. The principle autoimmune diseases, nearly all of which have HLA associations are discussed. Transplantation and the influence of HLA matching on engraftment are covered. The relationship between HLA polymorphism and resistence to infectioius disease is explored. Finally, there is an update on the advances in HLA typing where advances in serology, cellular techniques and recombinant DNA methods have improved the characterisation of the polymorphism and the practicalities of typing.