Pharmaceutical Toxicology
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Author(s): G. J. Mulder and L. Dencker (Eds)
Publisher: Pharmaceutical Press
ISBN: 0853695938
Format: softback
257pp
Price: £29.95
Review Date: 15 September 2006
Review: This book student textbook covers the basics of drug safety sciences. It combines a broad treatment of the safety issues that are relevant for assessing the efficacy/safety balance of new drugs with information on the toxicological knowledge base and methodology. The book begins with a general introduction to basic toxicology principles, then the organ toxicity of drugs is illustrated by chapters on the liver, kidneys, the respiratory system and the immune system. Specialised issues for safety/efficacy assessments of new drugs or drug indications are teratology and genotoxicity/carcinogenicity. The mechanistic aspects as well as the methodology of safety assessment and pharmacovigilence are dealt with.