Exploiting Chemical Diversity for Drug Discovery
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Author(s): P. Bartlett and M. Entzeroth (Eds)
Publisher: Royal Society of Chemistry
ISBN: 0854048421
Format: hardback
420pp
Price: £119.95
Review Date: 02 August 2006
Review: In the last decade drug discovery has undergone a dramatic evolution. The closer integration of chemistry, biology, and technology that is transforming drug discovery has stimulated advances in numerous areas at the interfaces of thee disciplines. The chapters of this book address separate aspects of this on-going transformation, with individual chapters reflecting the integration of different disciplines, techniques, and viewpoints. The book is divided into five sections: Operational developments in chemistry; Conceptual advances in synthetic ‘prospecting’ – design of discovery libraries and the search for hits; Conceptual advances in synthesis –‘mining’ – turning a hit into a lead; Operational developments in screening and high-throughput assays; and Conceptual advances in lead evaluation – screen early and often.