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| Assessing Oral Bioavailability of Metals in Soils | Buy a book...
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| Author(s): | M. Kelley, S. Brauning, R. Schoof and M. Ruby |
| Publisher: | Battelle Press |
| ISBN: | 157477123X |
| Format: | hardback |
| 124pp | |
| Price: | $65.00 |
| Review Date: | 14 November 2002 |
| Review: | In toxicology, ‘bioavailability’ refers to how much of a chemical is ‘available’ to have an adverse effect on humans or other organisms. The bioavailability depends on exposure dose and risk as well as risk-based clean-up levels. It is also influenced by physical and chemical factors, such as the form of the metal in the soil, and internal biological factors, such as the mechanisms of absorption into a living organism. This book explains concepts, identifies methods and data for assessing bioavailability, and shows how bioavailability adjustments can be incorporated into risk assessments to generate risk-based cleanup values that are more site-specific than those based on default assumptions. Situations for conducting a study are identified, the method of conducting a bioavailability study is described, and the factors involved in assessing the results are explained. |