Essays in Biochemistry. Proteases in Biology and Medicine
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Author(s): N. Hooper (Ed.)
Publisher: Portland Press
ISBN: 1855781476
Format: softback
201pp
Price: £19.00, $28.50
Review Date: 29 October 2002
Review: This textbook in the series Essays in Biochemistry contains fourteen essays on the role of proteases in biological processes. The cell cycle, blood clotting, angiogenesis, apoptosis, cell differentiation and growth, cellmotility, lipid metabolism, antigen presentation and cell-fate determination are all dependent on the controlled action of proteases. If the activity of the proteases is not regulated correctly, disease processes can occur, as in Alzheimer’s disease, cancer metastasis and tumour progression, inflammation, pain, atherosclerosis and haemophilia. The essays cover such topics as: capases and apoptosia, matrix metalloproteinases, the ubiquitin–proteasome pathway of intracellular proteolysis, methionine aminopeptidases and angiogenesis, proteases in blood clotting, anatomy and pathology of HIV-1 peptidase, and the shedding of membrane proteins by ADAM family proteases.