Pain and Neurological Inflammation
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Author(s): S. D. Brain and P. K. Moore
Publisher: Birkhäuser
ISBN:  3 7643 5875 0
Format: hardback
  344pp
Price: sFr218
Review Date: May 23, 2000
Review: This provides an up-to-date review of the mechanisms and consequences of both pain and neurological inflammation. Although pain and inflammation are inextricably linked, there is often a division of knowledge in scientific literature. Here, the authors aim to bridge the gap in knowledge of the two processes. The book begins by concentrating on pain mechanisms, the activation of sensory nerves by capsaicin, the painful and pro-inflammatory extract of peppers and chilies, the anatomy of sensory nerves and their interactions with the central nervous system, together with the interactive roles of the hyperalgesic kinins. Nitric oxide and inflammatory pain is also discussed. The hyperalgesic mechanisms that are relevant to individual tissues and organs are then covered, followed by a close investigation of the mechanisms of the inflammatory response. The final chapters discuss mechanisms that are relevant to aging and wound healing and the current situation with respect to the pharmacology of CGRP and tachykinin receptors and the efforts that have been made to develop selective neirokinin receptor antagonists.